Lowess normalization broken
Description (last modified by )
This problem affects all versions of BASE2.
As pointed out in the BASE users mailing list (http://email@example.com/msg01478.html) there is a flaw in the lowess plug-in shipped with BASE. Users using the original BASE1 distributed lowess plug-in with the Base1PluginExecuter wrapper are not affected.
The fix is a simple one line change but affects all bioassays normalized with lowess and consequently all analysis following a lowess normalization must be redone. The changes to be expected to analysis results varies with raw data quality, where good quality raw data will have little effect from the miscalculation in the lowess plug-in.
Change History (9)
comment:1 by , 16 years ago
|new → assigned